Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S33

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   E   Q   L   T   Q   P   E   S       L   T   V   R   P   G   Q   P   L   T
  AJ274717,IGHV3S33*01, 12-02b  TGT GAA CAG CTT ACT CAG CCC GAG TCT ... CTG ACT GTC CGA CCT GGT CAA CCT CTG ACC

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   S   Y   S   V   S   S   H   Y                       T   A
  AJ274717,IGHV3S33*01, 12-02b  ATC CGC TGT CAG GTC TCT TAT TCT GTT AGT AGC CAC TAC ... ... ... ... ... ACA GCT

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   H   A   L   E   W   I   G   W   T   R   T   D   G
  AJ274717,IGHV3S33*01, 12-02b  TGG ATC AGA CAA CCT GAA GGA CAT GCA CTG GAA TGG ATT GGT TGG ACT CGT ACC GAT GGC

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   K   V   K   D   S   L   S       S   Q   F   S   L   A   V
  AJ274717,IGHV3S33*01, 12-02b  AAA ... ... ... ... AAA GTG AAA GAC TCC CTT AGT ... AGT CAA TTC AGT CTT GCA GTT


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   G   S   S   N   T   V   T   L   Q   G   Q   N   M   Q   P   G   D   S   A
  AJ274717,IGHV3S33*01, 12-02b  GAC GGA TCC AGT AAC ACA GTA ACT TTG CAA GGG CAG AAC ATG CAG CCT GGA GAC TCA GCT

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   S
  AJ274717,IGHV3S33*01, 12-02b  GTG TAT TAC TGT GCC AGC     #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc